Bioactive Natural Products: Endophytic fungi are a rich source of new and biologically active natural products.

http://www.uff.br/RVQ/index.php/rvq/article/viewFile/275/280

Fungos Endofíticos: Uma Fonte Inexplorada e Sustentável de Novos e Bioativos Produtos Naturais

Vanessa M. Chapla,Carolina R. Biasetto e Angela R. Araujo

Universidade Estadual Paulista “Júlio de Mesquita Filho’’, Núcleo de Bioensaios, Biossíntese e

Ecofisiologia de Produtos Naturais (NuBBE), Instituto de Química

Araraquara SP  Brasil        araujoar@iq.unesp.br

Endophytic Fungi: An Unexplored and Sustainable Source of New and

Bioactive Natural Products

Endophytic fungi are a rich source of new and biologically active natural products. They

colonize a relatively unexplored ecological habitat and their secondary metabolism is particularly

active, presumably due to metabolic interactions with their hosts. In the course of our continuing investigations for new and bioactive compounds from endophytic fungi from brazilian flora Alibertia macrophylla, Caseria sylvestris, Ocotea corymbosa,Cassia spectabilis,Piper aduncum, Cryptocaria mandioccana, Xylopia aromatica and Palicourea marcgravii

were investigated. Forty two natural products were isolated and their structures were established on the basis of comprehensive spectral analysis, mainly using 1D and 2D NMR experiments. The compounds were tested in their antifungal, antioxidant, anticholinesterasic and anticancer activities.